Abstract The methanol extract of leaves of Moringa oleifera was evaluated for its antidiabetic efficacy in streptozotocin induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin ( 45 mg/kg body weight). Methanol extract administered kinerja kepala sekolah orally at dose of 300 mg/kg body weight for 35 days in diabetic rats. Blood glucose level, liver glycogen, muscle glycogen, insulin as well as initial and final changes in body weight were evaluated.
Introduction Diabetes is a complex administrasi kepala sekolah lengkap multisystemic disorder characterized by a relative or absolute insufficiency of insulin secretion and disturbances in carbohydrate, protein, lipid metabolism. [1,2] It is an insidious disease. Although the prevalence of diabetes is increasing, diabetes is not homogenously distributed throughout the population.[3] -Diabetes- means siphon and -mellitus- stands for sweet. Many of traditional medicinal plants have been used successfully since ancient times to treat diabetes and related complications because plants have been the major source of drugs for the treatment of diabetes mellitus in Indian system of medicine and other ancient systems in the world, though their biologically active compounds are unknown. [6] Ethnobotanical information indicates that more than 800 plants are used as contoh soal ukg traditional remedies for the treatment of diabetes due to their effectiveness, less side effects and relatively low cost. [7] Botanical products can improve glucose metabolism and the overall condition of individuals with diabetes not only by hypoglycemic effects but also by improving lipid metabolism, antioxidant status and capillary function. [8] Recently numerous traditional medicinal plants were tested for their antidiabetic potential in the experimental animals. In the present investigation is directed to the exploration of antidiabetic efficacy of the methanol extract of leaves of Moringa oleifera . The plant was reported to contain various amino acids, fatty acids, vitamins and its constituents such as leaf, flower, fruit and bark have been anecdotally used as herbal medicine in the treatment for inflammation, paralysis and hypertension, psychosis, eye diseases, fever and as an aphrodisiac. It is highly potent anti-inflammatory, hepatoprotective, antihyperytensive and anti-tumor [13,14] which for centuries has been advocated for traditional and industrial uses. All parts of the Moringa tree are edible and have soal tes tpa long been consumed by humans. It is mother's best friend because it increases woman's milk production. It is reported to elicit good clinical response in children suffering from upper respiratory tract infection
a most widely used chemical diabetogen
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